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Vol 52 (2021)
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Protective effect of Sika Deer bone polypeptide extract on dexamethasone-induced osteoporosis in rats | An | Electronic Journal of Biotechnology
doi:10.1016/j.ejbt.2021.04.002
Electronic Journal of Biotechnology, Vol 52 (2021)

Protective effect of Sika Deer bone polypeptide extract on dexamethasone-induced osteoporosis in rats

Liping An, Liqiang Shi, Yujie Ye, Dankai Wu, Guangkai Ren, Xiao Han, Guangyu Xu, Guangxin Yuan, Peige Du



Abstract

Background: Osteoporosis attacks approximately 10% of the population worldwide. Sika Deer (Cervus nippon), one of China’s precious traditional medicinal animals, has been widely recorded in ancient Chinese medical books and claimed for centuries to have numerous medical benefits including bone strengthening. This study aimed to find the use of Sika Deer bone in treating osteoporosis according to traditional records and to investigate the protective effect of Sika Deer bone polypeptide extract on glucocorticoid-induced osteoporosis (GIOP) in rats.

Results: Sika Deer bone polypeptide extract could increase serum Ca2+ and BGP, decrease serum P3+, ALP, PTH, and CT, but had no effect on serum NO in rats with GIOP. The immunohistochemical iNOS results of the rats’ distal femur were negative in each group. Besides the model group, the eNOS color reaction in osteoblasts was strongly positive in the other three groups.

Conclusions: Sika Deer bone polypeptide extract can improve pathological changes in the microstructure and stimulate the expression of eNOS in osteoblasts. The protective effect on bone might be mediated by eNOS-dependent NO generation.




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ISSN:  0717-3458

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