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Characterization of Lactobacillus fermentum UCO-979C, a probiotic strain with a potent anti-Helicobacter pylori activity | García | Electronic Journal of Biotechnology
doi:10.1016/j.ejbt.2016.11.008
Electronic Journal of Biotechnology, Vol 25 (2017)

Characterization of Lactobacillus fermentum UCO-979C, a probiotic strain with a potent anti-Helicobacter pylori activity

Apolinaria García, Karen Navarro, Enrique Sanhueza, Susana Pineda, Edgar Pastene, Manuel Quezada, Karem Henríquez, Andrey Karlyshev, Julio Villena, Carlos González



Abstract

Background: Helicobacter pylori is a microorganism considered the main risk factor in the development of gastric cancer. In this paper we inform a detailed characterization of the probiotic properties and the anti -H. pylori activity of a previously isolated lactobacillus strain - Lactobacillus fermentum UCO-979C - obtained from human gut.

Results: The strain tolerated pH 3.0, grew in the presence of 2% bile salts, produced lactic acid and hydrogen peroxide, aggregated in saline solution, showed high hydrophobicity, was highly adherent to glass and to Caco-2 and Gastric adenocarcinoma human cells (AGS) cells, showed an efficient colonization in Mongolian Gerbils, and it potently inhibited growth and urease activity of H. pylori strains. L. fermentum UCO-979C significantly inhibited H. pylori-induced IL-8 production in AGS cells and reduced viability of H. pylori. Regarding its innocuousness, UCO-979C was susceptible to several antibiotics. The strain did not produce histamine or beta hemolysis in blood agar containing red blood cells from various origins.

Conclusion: The results presented demonstrate that L. fermentum UCO-979C is a very good candidate as a probiotic able to protect humans against H. pylori infections.



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ISSN:  0717-3458

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